Curious about f-phenibut?
Do you wonder if f-phenibut is one of the best nootropics for improving mood and anxiety?
Then you’ve come to the right place.
Inside this detailed review, we break down everything you MUST know about f-phenibut, including the science behind it, its mechanism of action, its most important benefits, and the best place ot buy f-phenibut online.
We even answer your most important questions, including:
What is f-phenibut?
How does f-phenibut actually work?
Is Science.bio really the #1 online f-phenibut vendor?
We will be conducting a full f-phenibut review, including how to conduct safe research with this reference material, recommended doses for test participants, and most importantly, a guide to buying from the top online f-phenibut vendors.
P.S: Order F-Phenibut from our top rated vendor!
(Phenibut.com, sponsored) What is F-Phenibut?
What is F-Phenibut?
In the world of research chemicals, the term ‘analogue’ comes up frequently. Analogue simply means that the chemical structure and properties of one reference material is similar to another.
Research shows that approximately two-thirds of new research chemicals developed are analogues [1].
Pharmaceutical scientists design analogues for several reasons, including:
To improve the effects of an existing molecule (ie. lower dose required for experiments, longer duration of effects, improve safety profile).
Bypass legal restrictions to improve accessibility (an analogue may be legal, while the parent compound is not).
To design a new reference material that can be patented.
In the case of f-phenibut (also known as fluorophenibut), this research chemical was designed to improve on an already existing molecule, Phenibut [2].
For many years, Phenibut has been a highly sought after reference material in the research chemical community.
It is one of the only compounds that is consistently effective for both reducing anxiety and improving cognition in research participants [3].
F-Phenibut keeps all the positive benefits of regular Phenibut, while offering the advantages of:
Faster onset
Increased potency [2]
Shorter total duration
To achieve these effects, pharmaceutical scientists used the common method of fluorination to create an analogue of Phenibut. Fluorine-containing pharmaceuticals have been in use for over half a century, with approximately 20% of all current pharmaceuticals being fluorinated compounds [4].
In short, f-phenibut is simply Phenibut that has been chemically altered to include a fluorine atom.
Let’s take a look at some of the benefits of f-phenibut, so qualified researchers can make an informed choice about which form of Phenibut is most suited to their testing needs.
Benefits of F-Phenibut
The benefits of f-phenibut closely align with those of Phenibut — a compound that was designed in the Soviet Union in the 1960′s and is still prescribed in several CIS countries today [5].
Because there aren’t many studies on f-phenibut, it’s necessary to look at research on Phenibut to investigate the potential properties further.
Benefits of f-phenibut (and Phenibut) for research purposes include:
Reduction in anxiety [3]
Improves mood [6]
Effective treatment for insomnia [5]
A potential replacement for alcohol for social challenges
Increase in energy, particularly at lower doses
Helpful for dealing with times of stress [5]
Used medically for the treatment of alcoholism, PTSD, depression, anxiety, stuttering, and tics [7]
Useful for treating nerve pain (similar to all drugs in its class) [8]
F-Phenibut is in a class of compounds called gabapentinoids [9], which includes several commonly prescribed medications such as pregabalin (Lyrica), gabapentin (Neurontin), and baclofen (Lioresal).
These medications are now regularly used in the treatment of anxiety [10], pain [8], and many other medical issues.
When it comes to f-phenibut vs. Phenibut, neither is necessarily better. Research studies show similar effects from both, with f-phenibut having the following different characteristics to Phenibut.
1. Faster Onset
Phenibut can take a long time to take effect — up to 3 hours [3], even when administered to test subjects on an empty stomach. This is suitable if study participants have enough time to prepare, or when quick effects aren’t required, but it can be problematic otherwise.
The onset of effects of f-phenibut are generally reported to begin within 20 - 60 minutes.
This makes f-phenibut the preferred option when a faster acting research compound is required, such as in experiments to treat panic attacks, unexpected stress, sudden onset of pain, or when advance planning is just not possible.
2. Increased Potency
One of the drawbacks of Phenibut is its low potency by weight. This means that common doses administered to research participants will often be quite large, in the realms of 500mg - 1,000mg per dose [11].
Doses of this amount can require either administering several capsules at a time, or dissolving powder into a liquid solution.
F-Phenibut is more potent [2], with effective test results being reported at approximately one fifth (20%) the dose of regular Phenibut (100mg - 200mg).
This makes f-phenibut a far more convenient chemical to research than Phenibut.
A full dose can easily be administered to a test subject in a single capsule, plus the relatively small amount of powder can be given sublingually (under the tongue).
3. Shorter Duration
Experiments show that the effects of Phenibut can be present for up to 24 hours after administration [3], while f-phenibut wears off within 8 hours.
Depending on the needs of research participants, sometimes a shorter acting chemical than Phenibut is more suitable for experiments.
For example, if research participants have to drive home from a study, need to work the following day, or are trying to get to sleep fast and not feel impaired the next day, f-phenibut will be preferable to Phenibut.
How to Research F-Phenibut Safely
Data from countries where Phenibut is prescribed [12] can be used to determine important safety guidelines for conducting research with f-phenibut.
The main complications for regular research participants are dependence and withdrawal. Both can be avoided by qualified researchers carefully controlling the doses administered to test participants and frequency of experiments.
Dose
Because it is quite a potent chemical, attention must be paid to ensuring correct dosing of f-phenibut. Researchers should always use an accurate scale to measure doses in powder, or purchase pre-filled capsules from a reliable vendor.
For participants that are new to research with f-phenibut, a starting dose of no more than 50mg is recommended for the first few experiments [7].
This can be gradually increased as needed, but bear in mind that the higher the dose of f-phenibut administered, the higher the risk that dependence and withdrawal will be experienced by test subjects.
Tolerance will also build with increased doses [13], meaning that higher amounts will be required during research to achieve the same results.
Frequency of Administration
To ensure safety in experiments with f-phenibut, it is recommended to restrict administration to test subjects to between 1—3 days per week. It is preferable that research participants are given at least one day off between each day of testing.
On days where research is conducted, f-phenibut can be tested up to a maximum of three times per day [7].
By keeping to this schedule, research participants should experience minimal tolerance and will largely avoid any challenges with dependence or withdrawal.
It is important for test participants to be given ‘tolerance breaks’ from any research chemical [14]. Taking 1 - 4 weeks off testing completely a few times per year will allow brain chemistry to recalibrate. Sticking to this will allow researchers and test participants to continue experiencing benefits from f-phenibut for many years to come.
Things to Avoid
In addition to the above, there are a few things to avoid in f-phenibut research:
Individual doses should not exceed 250mg
Test participants should not mix with alcohol, medication, or recreational drugs [5]
Driving, swimming, or other potentially dangerous activity should be avoided by test subjects while f-phenibut is being researched [7]
(Phenibut.com, sponsored) Warning and Precautions.
Warning and Precautions
If the guidelines above are followed, it is unlikely that any adverse effects will be experienced by participants in f-phenibut research. Even so, there are some potential adverse effects that researchers need to be aware of.
1. Dependence
Just like any psychoactive substance (alcohol, coffee, nicotine), test participants can become dependent on f-phenibut [15].
Dependence describes the situation where regular test subjects have difficulty going without f-phenibut and have severe withdrawals between experiments.
The best way to avoid dependence during research is to stick to recommended guidelines around dosage and frequency of use for test participants.
2. Withdrawal
Research on Phenibut gives us some good information on the nature of withdrawal symptoms that test participants could experience from f-phenibut [16].
Withdrawal occurs when a research subject that has become dependent on f-phenibut abstains from experiments, or is administered a reduced dose.
Withdrawal can be incredibly unpleasant and includes symptoms such as [17]:
Anger and irritability
Severe anxiety
Difficulty sleeping
Nausea
Depression and low mood
Difficulty concentrating
Muscle aches and pain
In general, withdrawal symptoms from f-phenibut are the opposite of potential benefits for test subjects, but amplified greatly.
3. Overdose
It is possible for test participants to be administered an overdose of f-phenibut.
A general rule of thumb, anything exceeding 500mg of f-phenibut at one time can be considered an overdose.
Dizziness, vomiting, loss of balance, slurred speech, extreme drowsiness, shallow breathing, and loss of consciousness, are some of the symptoms of Phenibut [12] and f-phenibut overdose.
In high dose experiments, Phenibut and f-phenibut can act as central nervous system depressants [18]. This means overdose presents the same risks for test participants as with classes of drugs like opioids and sedatives.
4. Dealing With Dependence and Withdrawal
The easiest way for qualified researchers to deal with dependence and withdrawal in test participants is to avoid them in the first place.
If it’s too late for that and a research participant is experiencing problems, the best approach is to develop a tapering plan [19].
In general, this involves making an accurate assessment of the daily/weekly amount of f-phenibut being administered, then gradually reducing this to minimize withdrawal symptoms.
Tapering is complicated and must be done with care. Guidelines can be found online, but it is recommended to seek guidance from a medical professional.
5. F-Phenibut Side Effects
Like all research chemicals, a small proportion of test subjects may experience side effects from f-phenibut.
Using the research on Phenibut as a guide, we would expect only around 5% of research participants to experience side effects [5].
Possible side effects include [7]:
Tiredness
Nausea
Drowsiness
Feeling itchy
Headache
Difficulty with coordination
In the vast majority of studies, side effects can be eliminated or significantly minimized by reducing the dose of f-phenibut administered to test subjects.
F-Phenibut Dosage Guide and Calculator
Because it has never been used as a prescribed medication, there are no clinical trials specifying an exact dosage guide for f-phenibut.
Nevertheless, we do have access to scientific [2] and anecdotal [20] data indicating that it is approximately five times the strength by weight of regular Phenibut.
Using evidence based data on recommended doses of Phenibut HCL [5], the following is a recommended guide for calculating for f-phenibut dosage:
Low dose: 50 — 75mg
Medium dose: 125 — 150mg
High dose: 250mg+
For qualified Phenibut researchers, an appropriate formula for converting a dose of Phenibut HCL to an equivalent f-phenibut dose is:
Phenibut HCL Dose x 0.2 = Equivalent Dose Of F-Phenibut
For example, a study using 500mg doses of Phenibut HCL, could be converted to use f-phenibut by the following calculation:
500 (Phenibut HCL) x 0.2 = 100 (Equivalent F-Phenibut Dose In Milligrams)
Where to Buy F-Phenibut Online?
One of the most important considerations when looking to buy f-phenibut is what vendor to purchase from.
Choosing a trusted vendor will help avoid some of the common pitfalls with ordering research chemicals online, including:
Poor packaging and labeling leading to customs issues
Receiving a contaminated or impure product
Unclear instructions or defective capsules leading to dosing mistakes
Product not arriving at all!
Mix-ups with the product provided
To save qualified researchers the trouble, we have been through the main online f-phenibut vendors and settled on the following two as our top choices.
1. Science.Bio
Science.Bio is the most trusted online F-Phenibut vendor. They are a reputable provider of high-quality reference materials for life science research.
When you choose Science.Bio, you can expect the following:
Third-Party Testing: They test all of their products using rigorous 3rd-party testing protocols, including providing certification of analysis for all products. With Science.bio, you know you are getting the highest quality f-phenibut available online.
Quality Control Practices: Science.bio uses the strict quality control measures, including transparent batch & lot tracking. This is done to ensure the products are as pure as possible for your most important research studies.
Range of Products: Science.bio offers more than just f-phenibut - they also manufacture a wide variety of nootropics, cognitive enhancers, and other research chemicals. You can think of Science.bio as the #1 source for all of your research chemical needs.
Competitive Pricing: Science.bio offers some of the best prices anywhere in the world for f-phenibut and other products.
Free Shipping: Science.bio offers free USPS Priority Mail and Fedex 2Day shipping for anyone placing an order over $100!
Overall, Science.Bio is the most trusted online vendor for high-quality nootropics and cognitive enhancers, including f-phenibut. They have the highest quality products, and a commitment to impeccable customer service.
But don’t just take our word for it - here are what real-world customers are saying about Science.bio:
“Probably the only place you’ll want to get sarms / nootroopics. Always ships out in a day or 2, everything has multiple lab reports. Anything I’ve ever bought has never been anything less than completely 100% potent and accurately dosed. Highly recommended!” - John R
If you’re serious about using the highest quality f-phenibut for your most important researchers, then Science.bio is the clear #1 choice.
2. Pure Rawz
Pure Rawz is another excellent choice for anyone interested in purchasing premium-quality F-Phenibut online. Of course, they also sell a wide variety of nootropics that you can also choose from.
Pure Rawz is unique because they truly understand the needs of hardcore researchers. All of their products go through rigorous 3rd-party testing protocols to check for purity and potency.
Benefits of ordering F-Phenibut through Pure Rawz include:
Premium quality F-Phenibut including fine crystals, capsules, and powders
Strict quality control measures for all of their products, ensuring potency and purity
One of the largest selections of nootropics and other research chemicals
Free shipping on orders over $69, and all products ship within 24 hours of purchase
(Phenibut.com, sponsored) F-Phenibut vs. Phenibut HCL.
F-Phenibut vs. Phenibut HCL
F-Phenibut and Phenibut HCL are two closely related nootropics and cognitive enhancers.
They have similar effects in the body, but they also have key differences that you need to be aware of before using them in your research studies.
What Is F-Phenibut?
F-Phenibut is a newer and potentially stronger derivative of Phenibut. Research shows it offers increased potency and longer-lasting effects vs Phenibut HCL.
Here are some ways that f–phenibut differs from the more traditional Phenibut HCL:
Longer Half-Life: The effects of f-phenibut last for approximately 8 hours, which means it can be taken less frequently to achieve the same effects as Phenibut HCL.
Greater Potency: F-Phenibut is approximately 5 times more potent than Phenibut HCL, which means smaller doses are needed to achieve similar effects.
Less Established Safety Profile: F-Phenibut is a newer research chemical, and has less overall research vs Phenibut HCL. For this reason, increased caution is warranted when studying the effects of f-phenibut.
What Is Phenibut HCL?
Phenibut HCL is a well-established nootropic that has been successfully studied for decades for reducing symptoms of anxiety and improving overall mood in research studies.
Key facts about Phenibut HCL include:
Short Half-Life: Phenibut HCL has a relatively short half-life of around five hours. This means research subjects need to take it multiple times throughout the day to maintain similar effects.
Lower Potency: Phenibut HCL is less potent than F-Phenibut and requires higher overall doses to achieve optimal effects in the body.
Established Safety Profile: Phenibut HCL is an extremely safe research chemical, ad has been successfully studied for decades with minimal side effects.
F-Phenibut And Phenibut HCL | Which Is Best?
Ultimately, f-phenibut and Phenibut HCL are both viable research chemicals for improving mood and decreasing anxiety-related symptoms in research subjects.
However, they do have some key differences that researchers must be aware of:
Potency: F-Phenibut is 5x more potent than Phenibut HCL, and requires a much smaller dose of 100 - 200 mg to achieve optimal benefits.
Duration of Action: The effects of f-phenibut last slightly longer than those of Phenibut HCL (8 hours vs 5 hours), meaning f-phenibut can be taken less frequently to achieve similar benefits.
Safety Profile: Phenibut HCL has more research backing its safety and efficacy. While research does show f-phenibut to be a safe research chemical when taken at the correct dosage, increased caution should be used when studying its effects.
In conclusion, both f-phenibut and Phenibut HCL offer similar benefits, but they differ in terms of their potency, duration of action, and safety profile.
Researchers are encouraged to carefully consider the pros and cons of each compound before studying their effects.
F-Phenibut Review | Overall
Many qualified researchers avoid f-phenibut, even if they are familiar with its parent compound, Phenibut.
It’s true that f-phenibut has not been studied as extensively as Phenibut. But for certain applications, it offers some distinct benefits over Phenibut.
Benefits of f-phenibut over Phenibut include:
Faster effects
Requires a lower overall dose
Has a shorter duration of effects
Researchers who take the time to conduct experiments with f-phenibut will learn that the question to ask is not, which compound is better out of f-phenibut vs Phenibut? But, which is best suited to my particular research needs, for each specific experiment?
In this review we have covered all of the information researchers need to know about f-phenibut, including essential information about the compound, safe testing guidelines, and trusted vendors.
If these guidelines are followed, qualified researchers can be confident in conducting safe and enjoyable experiments with f-phenibut for many years to come.
Order F-Phenibut by clicking here!
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